What is a common adverse effect of ibuprofen?

Gastrointestinal discomfort is a well-known adverse effect of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID). This discomfort can manifest as symptoms such as stomach pain, heartburn, nausea, or even more severe conditions like ulcers or gastrointestinal bleeding, especially with prolonged use or at higher doses. Ibuprofen works by inhibiting enzymes involved in the inflammatory process, but this inhibition can also affect the production of protective stomach lining, leading to upset stomach or more serious GI complications.

The other potential adverse effects listed, such as excessive sleepiness, increased blood pressure, and rapid heartbeat, are not the most common side effects associated with ibuprofen. While elevated blood pressure could be a potential concern for some individuals on a long-term basis, gastrointestinal discomfort remains the primary and most frequent complaint among users of ibuprofen.