What are common contraindications for NSAIDs?

The selection of asthma, gastrointestinal ulcers, and renal impairment as common contraindications for NSAIDs is rooted in clinical practice and the pharmacological effects of these medications.

Asthma can be relevant because NSAIDs, particularly non-selective ones, can induce bronchospasm in some patients who are sensitive to aspirin or similar medications. Therefore, those with asthma may be at higher risk when taking these drugs.

Gastrointestinal ulcers are significant contraindications because NSAIDs can inhibit the production of prostaglandins, which help protect the stomach lining. This inhibition can lead to worsened ulcer conditions or increase the risk of bleeding and perforation, making it critical for patients with a history of gastrointestinal issues to avoid these medications.

Renal impairment is another important contraindication since NSAIDs can reduce renal blood flow and lead to or exacerbate kidney dysfunction. In patients with existing renal issues, the use of NSAIDs can precipitate further renal failure due to their effects on the renal vasculature.

The other options include conditions that may warrant caution or close monitoring but are not universally classified as contraindications for NSAIDs in the same way as the three identified in the correct answer.